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Mitsuaki Isobe Selected Research

Cardiac Myosins

12/2013Inhibition of NF-κB activation by a novel IKK inhibitor reduces the severity of experimental autoimmune myocarditis via suppression of T-cell activation.
6/2006A CCR1 antagonist prevents the development of experimental autoimmune myocarditis in association with T cell inactivation.
4/2005Hepatocyte growth factor ameliorates the progression of experimental autoimmune myocarditis: a potential role for induction of T helper 2 cytokines.
7/2003Attenuation of experimental autoimmune myocarditis by blocking activated T cells through inducible costimulatory molecule pathway.

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Mitsuaki Isobe Research Topics

Disease

52Atrial Fibrillation
10/2023 - 07/2005
34Heart Failure
01/2024 - 05/2003
25Myocardial Infarction
04/2024 - 11/2002
25Myocarditis (Carditis)
06/2021 - 07/2003
22Inflammation (Inflammations)
01/2023 - 07/2003
20Cardiovascular Diseases (Cardiovascular Disease)
11/2023 - 07/2003
17Takayasu Arteritis (Arteritis, Takayasu's)
01/2021 - 05/2006
16Fibrosis (Cirrhosis)
03/2019 - 01/2006
15Atherosclerotic Plaque (Atheroma)
01/2022 - 03/2006
14Myocardial Ischemia (Ischemic Heart Diseases)
12/2023 - 11/2003
12Thrombosis (Thrombus)
09/2023 - 07/2008
12Hyperplasia
08/2017 - 04/2003
12Tachycardia (Tachyarrhythmias)
05/2017 - 09/2004
11Cardiac Arrhythmias (Arrythmia)
01/2022 - 09/2006
10Ventricular Tachycardia
10/2023 - 11/2002
10Stable Angina
07/2017 - 05/2002
10Ventricular Remodeling
01/2013 - 01/2006
9Hemorrhage
06/2023 - 01/2013
9Hypertension (High Blood Pressure)
01/2021 - 10/2010
8Aortic Valve Stenosis (Aortic Stenosis)
07/2022 - 01/2011
8Ischemia
07/2019 - 08/2003
8Hypertrophy
05/2018 - 08/2006
8Acute Coronary Syndrome
11/2017 - 03/2008
8Heart Diseases (Heart Disease)
07/2017 - 06/2006
8Infarction (Infarctions)
01/2017 - 11/2003
8Reperfusion Injury
02/2011 - 11/2003
7Neointima
02/2017 - 12/2002
6Atrioventricular Block
10/2023 - 03/2003
6Stroke (Strokes)
01/2023 - 08/2013
6Atherosclerosis
10/2022 - 06/2003
6Sarcoidosis (Schaumann Disease)
06/2022 - 03/2003
6Peripheral Arterial Disease
10/2020 - 04/2015
6Atrial Flutter (Flutter, Atrial)
10/2020 - 05/2003
6Pathologic Constriction (Stenosis)
01/2020 - 03/2006
6Brugada Syndrome
06/2017 - 03/2003
6Disease Progression
01/2012 - 09/2002
5Shock
11/2023 - 06/2006
5Frailty
07/2023 - 01/2018
5Spasm (Spasms)
10/2022 - 09/2007
5Chronic Renal Insufficiency
12/2019 - 12/2012
5Cardiomegaly (Heart Hypertrophy)
04/2017 - 08/2006
4Aortic Valve Insufficiency (Aortic Regurgitation)
12/2023 - 01/2012
4Death (Near-Death Experience)
01/2023 - 01/2014
4Neoplasms (Cancer)
10/2022 - 03/2011
4Coronary Artery Disease (Coronary Atherosclerosis)
10/2022 - 06/2004
4Rupture
01/2018 - 01/2011
4Vascular Remodeling
11/2016 - 12/2002
4Infections
10/2016 - 08/2003
4Vascular System Injuries
06/2008 - 04/2004
3Mitral Valve Insufficiency (Mitral Regurgitation)
10/2023 - 04/2005
3Cardiomyopathies (Cardiomyopathy)
09/2023 - 02/2011
3Dementia (Dementias)
07/2023 - 09/2019
3Periodontitis
01/2023 - 09/2015

Drug/Important Bio-Agent (IBA)

12LipidsIBA
01/2018 - 06/2007
11Matrix Metalloproteinases (MMPs)IBA
12/2012 - 12/2002
10Biomarkers (Surrogate Marker)IBA
10/2022 - 01/2010
10Proteins (Proteins, Gene)FDA Link
01/2019 - 09/2002
10CytokinesIBA
09/2017 - 07/2003
9Brain Natriuretic Peptide (Natrecor)FDA Link
03/2022 - 09/2006
8NF-kappa B (NF-kB)IBA
07/2013 - 07/2004
6omega-Chloroacetophenone (Mace)IBA
01/2023 - 06/2006
6Adenosine Triphosphate (ATP)IBA
01/2015 - 05/2002
5Serum AlbuminIBA
10/2023 - 01/2019
5SteroidsIBA
10/2022 - 01/2012
5AnticoagulantsIBA
01/2021 - 08/2013
5Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
05/2018 - 12/2004
5Peroxisome Proliferator-Activated Receptors (PPAR)IBA
09/2013 - 06/2003
5Adenosine (Adenocard)FDA LinkGeneric
05/2013 - 05/2007
5TeaIBA
01/2009 - 06/2005
4Indicators and Reagents (Reagents)IBA
04/2024 - 10/2013
4GlucocorticoidsIBA
01/2023 - 01/2017
4C-Reactive ProteinIBA
01/2020 - 02/2012
4Insulin (Novolin)FDA Link
12/2019 - 03/2003
4SaltsIBA
05/2018 - 03/2005
4CalciumIBA
01/2018 - 01/2012
4Angiotensin IIIBA
01/2017 - 08/2006
4Transcription Factors (Transcription Factor)IBA
11/2016 - 07/2008
4Cardiac MyosinsIBA
12/2013 - 07/2003
4Telmisartan (Micardis)FDA Link
08/2012 - 05/2010
4PPAR gammaIBA
06/2011 - 06/2006
4Dinoprostone (PGE2)FDA Link
03/2011 - 01/2009
4Plasminogen Activator Inhibitor 1IBA
02/2011 - 07/2008
4Glucose (Dextrose)FDA LinkGeneric
01/2008 - 03/2003
3Gallium-67IBA
10/2023 - 03/2003
3Immunosuppressive Agents (Immunosuppressants)IBA
01/2023 - 01/2012

Therapy/Procedure

41Catheter Ablation
01/2022 - 05/2003
36Therapeutics
09/2023 - 04/2005
19Percutaneous Coronary Intervention
01/2022 - 03/2008
18Stents
07/2019 - 03/2006
13Transcatheter Aortic Valve Replacement
07/2023 - 01/2011
10Implantable Defibrillators (Implantable Cardioverter-Defibrillator)
11/2023 - 06/2006
9Cardiac Rehabilitation
04/2024 - 01/2019
9Heart Transplantation (Grafting, Heart)
01/2022 - 06/2004
6Renal Dialysis (Hemodialysis)
06/2023 - 06/2014
6Ligation
04/2016 - 01/2007
5Patient Readmission
01/2024 - 02/2008
5Catheters
05/2019 - 05/2004
4Lasers (Laser)
06/2022 - 03/2007
4Drug Therapy (Chemotherapy)
07/2017 - 07/2005
3Punctures
10/2022 - 07/2008